This kind of Acute Respiratory Failure is caused by violation of nervous impulse transfer from a respiratory center to respiratory muscles or by the proper pathology of respiratory muscles.

✓ The Pathology of impulse conduction by neurotransmitter system. This kind of Neuromuscular Acute Respiratory Failure arises at traumas and spinal cord diseases (especially cervical vertebrae) and abducent nerves:

• traumatic intersection
• tumours
• ischemic problems
• inflammation of the bacterial or virus origin
• amyotrophic lateral sclerosis
• traumas
• demyelination
• poliomyelitis
• polyneuropathy (Guillain-Barré Syndrome).

A special attention is paid to nervus phrenicus, innervating a diaphragm as a secondary weakness of a diaphragm can develop after its damage.

✓ The Pathology of impulse conduction in neuromuscular junction. This kind of Neuromuscular Acute Respiratory Failure arises at autoimmune damage of synaptic mediators (myasthenia), toxic lesion of synapse mediators (botulism, tetanus, phosphoric poison) or its medicamentous depression (muscle relaxants).

✓ The Pathology of respiratory muscles contraction. A number of various causes can lead to the weakness of respiratory muscles. Some of them are:

• nonspecific myopathies
• miodistrofiya
• collagen disease
• general attrition (cachexy).

Neuromuscular Acute Respiratory Failure as well as Central Acute Respiratory Failure belong to so-called ventilating, or hypoxic-hypercapnic respiratory insufficiency. During this ventilating respiratory insufficiency (=ventilating acute respiratory failure) an expressed alveolar hypoventilation occurs. A tidal volume sharply drops, therefore hypoxemia and hypercapnia progress simultaneously that is characteristic only for ventilating acute respiratory failure. At all cases of ventilating acute respiratory failure an artificial lung ventilation should be started as soon as it possible.

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  Low Compliance?
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  The Work Of Breathing
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  Central Acute Respiratory Failure
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  Obstructive Acute Respiratory Failure
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  Restrictive Acute Respiratory Failure
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  Perfusive Acute Respiratory Failure
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  The Six Main Reasons Of Extrapulmonary Acute Respiratory Failure
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