Any Symptoms Of Your Disease

Antiphospholipid Syndrome (APS/Hughes syndrome) is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids. The most common of these antibodies, lupus anticoagulant (LA) and anticardiolipin antibodies (aCL), are the basis of laboratory diagnosis. Primary Antiphospholipid Syndrome - thrombosis or multiple pregnancy loss with the laboratory findings of persistent paradoxical prolongation of activated partial thromboplastin time (aPTT) or high titers of aCL antibodies. Secondary Antiphospholipid Syndrome: associated with other autoimmune diseases, infection, drugs, and malignancy. Primary and secondary APS can result in venous or arterial thrombosis in virtually any location; lower extremity deep vein thrombosis (DVT) is the most common presentation. Thrombotic stroke/transient ischemic attack (TIA) is the leading arterial manifestation of APS. Up to 46% of stroke patients <50 years old have antiphospholipid antibodies.

Fact#1: Dyspareunia is persistent or recurrent pain with attempted or complete vaginal entry and/or penile vaginal intercourse.

Fact#2: The female postmenopausal population is particularly susceptible to dyspareunia because of vaginal hypoestrogenism.

Fact#3: In the National Health and Social Life Survey of 1,749 women, 43% of women surveyed experienced sexual dysfunction, which included the diagnosis of dyspareunia.

Fact#4: A study evaluating the chief complaint of women presenting to a specialty vulvovaginal clinic revealed that 70% (228/330) reported dyspareunia.

Acrocyanosis is characterized by painless, symmetric, bluish discoloration and coolness most commonly affecting hands and feet. The condition is exacerbated by cold exposure; however, some degree of cyanosis is often present continuously. Other areas affected are:

✓ nose

✓ ears

✓ lips

✓ nipples.